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About Clinical Immunology PDF Book

Offer your patients the best possible care with clear, reliable guidance from one of the most respected and trusted resources in immunology. Authoritative answers from internationally renowned leaders in the field equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems.

“This is a ‘must have’ book for any serious student of clinical immunology…I heartily recommend this book.”
Reviewed by: Dr Andy Gennery on behalf of the British Journal of Immunology, December 2013

Key Features

  • Depend on authoritative information from leading experts in the field who equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems.
    • Focus on the information that’s most relevant to your daily practice through a highly clinical focus and an extremely practical organization that expedites access to the answers you need.

    Table of Contents

    PART 1: Fundamental Principles of the Immune Response

    1 The human immune response
    2 Organization of the immune system
    3 Innate immunity
    4 Antigen receptor genes, gene products, and co-receptors
    5 The major histocompatibility complex
    6 Antigens and antigen processing
    7 Antigen-presenting cells and antigen presentation
    8 B-cell development and differentiation
    9 T-cell development
    10 Cytokines and cytokine receptors
    11 Chemokines and chemokine receptors
    12 Lymphocyte adhesion and trafficking
    13 T-cell activation and tolerance
    14 Programmed cell death in lymphocytes

    PART 2: Host Defense Mechanisms and Inflammation

    15 Immunoglobulin function
    16 Regulatory T cells
    17 Helper T-cell subsets and control of the inflammatory response
    18 Cytotoxic lymphocyte function and natural killer cells
    19 Host defenses at mucosal surfaces
    20 Complement and complement deficiencies
    21 Phagocytes and phagocyte deficiencies
    22 Mast cells, basophils and mastocytosis
    23 Eosinophils and eosinophilia

    PART 3: Infection and Immunity

    24 Immune response to extracellular bacteria
    25 Immune responses to intracellular bacteria
    26 Immune responses to spirochetes
    27 Immune responses to viruses
    28 I mmune responses to protozoans
    29 Immune responses to helminths

    PART 4: Immunologic Deficiencies

    30 Evaluation of the immunodeficient patient
    31 Infections in the immunocompromised host
    32 Development of the fetal and neonatal immune system
    33 Aging and the immune system
    34 Primary antibody deficiencies
    35 Primary T-cell immunodeficiencies
    36 Inherited disorders of IFN-γ-, IFN-α/β-, and NF-κB-mediated immunity
    37 HIV infection and acquired immunodeficiency syndrome
    38 Immunodeficiency due to congenital, metabolic, infectious,
    surgical, and environmental factors

    PART 5: Allergic Diseases

    39 Pathogenesis of asthma
    40 Management of the asthmatic patient
    41 Rhinitis and sinusitus
    42 Urticaria, angiodema, and anaphylaxis
    43 Allergic reactions to stinging and biting insects
    44 Atopic and contact dermatitis
    45 Food allergy
    46 Eosinophil-associated gastrointestinal disorders (EGID )
    47 Allergic disorders of the eye
    48 Drug hypersensitivity
    49 Occupational and environmental allergic disorders

    PART 6: Systemic Immune Diseases

    50 Mechanisms of autoimmunity
    51 S ystemic lupus erythematosus
    52 Rheumatoid arthritis
    53 Juvenile idiopathic arthritis
    54 Sjögren’s syndrome
    55 Systemic sclerosis
    56 Inflammatory muscle diseases
    57 Spondyloarthritis
    58 Small- and medium-vessel primary vasculitis
    59 Large-vessel vasculitides
    60 Autoinflammatory fever syndromes
    61 Antiphospholipid syndrome

    PART 7: Organ Specific Inflammatory Disease

    62 Immunohematologic disorders
    63 Bullous diseases of the skin and mucous membranes
    64 Myasthenia gravis
    65 Multiple sclerosis
    66 Autoimmune peripheral neuropathies
    67 Immunologic renal diseases
    68 Inflammation and atherothrombosis
    69 Autoimmune thyroid diseases
    70 Diabetes and related autoimmune diseases
    71 Immunologic lung diseases
    72 Sarcoidosis
    73 Immunologic ocular disease
    74 Immunologic disease of the gastrointesinal tract
    75 Inflammatory hepatobiliary cirrhosis

    PART 8: Neoplasia and the Immune System

    76 Lymphoid leukemias
    77 Lymphomas including Hodgkin lymphoma
    78 Monoclonal gammopathies
    79 Tumor immunology and immunotherapy

    PART 9: Transplantation

    80 Concepts and challenges in transplantation: rejection,
    immunosuppression and tolerance
    81 Challenges and potentials of xenotransplantation
    82 Hematopoietic stem cell transplantation for malignant diseases
    83 Stem cell transplantation and immune reconstitution
    in immunodeficiency
    84 Thymic reconstitution

    PART 10: Prevention and Therapy of Immunologic Diseases

    85 Immunoglobulin therapy: replacement and immunomodulation
    86 Gene transfer therapy of immunologic diseases
    87 Glucocorticoids
    88 Nonsteroidal anti-inflammatory drugs
    89 Antihistamines
    90 Immunomodulating pharmaceuticals
    91 Protein kinase antagonists as therapeutic agents for immunological
    and inflammatory disorders
    92 Vaccines
    93 Immunotherapy of allergic disease
    94 Cytokine therapy
    95 Monoclonal antibodies and fusion proteins

    PART 11: Diagnostic Immunology

    96 Assessment of proteins of the immune system
    97 Flow cytometry
    98 Assessment of functional immune responses
    99 Assessment of neutrophil function
    100 Assessment of human allergic diseases
    101 Molecular methods


    1 Selected CD molecules and their characteristics
    2 Laboratory reference values
    3 Chemokines
    4 Cytokines

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